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Martin Hjortso's Cell adhesion: fundamentals and biotechnological PDF

By Martin Hjortso

ISBN-10: 0824789458

ISBN-13: 9780824789459

Deals a close advent to the elemental phenomena that govern mobilephone adhesion and describes bioengineering procedures that hire cellphone adhesion, targeting either biochemical and biomedical functions. All industrially appropriate problems with phone adhesion - from uncomplicated strategies, quantitative experiments, and mathematical versions to purposes in bioreactors and different technique apparatus - are tested.

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Extra info for Cell adhesion: fundamentals and biotechnological applications

Example text

Diffusion coefficient of ligand in solution, the sum of the translational and rotational diffusion coefficients in solution (area/ time). Receptor diffusion coefficient in themembrane. Rotational diffusion coefficient in themembrane. Translational diffusion coefficient in the membrane. Fraction of volume occupied by liposomes. Tensile force on ligand-receptor bonds. Membrane thickness. Ligand flux. J K". Boltzmann's constant, Apparent rateconstant for ligand-receptor bond formation. Apparent rate constant for ligand-receptor bond breakup.

A generalization of the Young equation has been derived for this case (8), which can be used if the bonds are immobile and the continuum approximation is valid. However, as mentioned in Chapter 1, experiments have indicated (9) that, in cell-cell adhesion, the ligand-receptor bonds may be mobile and this mobility strongly affects the peeling process. As the membranes are pulled away from each other, the bond stress exerts a force on the receptors that pulls them back toward the adhered part of the membranes and, thus, concentrates bonds in the boundary of the contact area.

A rare case for which an analysis is possible isfor spherical cells that reach the adhesion surface via sedimentation. In suchcases, the timerequired for contact is the time needed for the sedimentation followed by drainage of the liquid film between the cell and the solid surface. This would show up as a delay or lag before cell adhesion begins. Such adhesion delays have in fact been observed experimentally The cell adhesion models that have been published in. the literature can roughlybedivided into twoclasses,which, by analogy withmicrobial growth models, may be termed segregated and nonsegregated models.

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Cell adhesion: fundamentals and biotechnological applications by Martin Hjortso


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